血脂康对培养的家兔主动脉平滑肌细胞增殖的影响

目的：探讨调脂中经血脂康对血管平滑肌细胞（VSMC）增殖的影响。方法：在培养的家兔主动脉VSMC中加入不同浓度的血脂康共同孵育24h，分别采用细胞计数及^3H－胸腺嘧啶核苷（^3H-TdR)掺入实验观察血脂康对VSMC增殖及MDA合成的影响。结果：血脂康明显抑制VSMC增殖（P＜0．05）和DNA合成（P＜0．01）。结论：血脂康既具有降低血脂作用，又可能通过抑制VSMC增殖而防止动脉粥样硬病变恶化及血管成形术后血管再狭窄等作用。

Effects of Xuezhikang on the Proliferation of Cultured Aortic Smooth Muscle Cells of Rabbits

Objective: Our aim was to investigate the effects of Xuezhikang, a traditional Chinese lipid adjusting drug, on the proliferation of vascular smooth muscle cells(VSMC). Methods: We used cell counting and 3H TdR incorporation tests to study the effects of Xuezhikang on the proliferation and DNA synthesis of VSMC after incubation the VSMC with different concentration of Xuezhikang for 24 hours. Results: Xuezhikang significantly inhibited the VSMC proliferation and DNA synthesis. Conclusion: Xuezhikang can inhibit the proliferation of VSMC. It may have potential therapeutic values to prevent restenosis after coronary angioplasty.