天麻粉不同粒径的镇静镇痛作用研究

目的：比较天麻超微粉和普通粉在药效学方面的差异。方法：同一批次天麻分别用细胞级粉碎和普通设备粉碎或超微粉和普通粉，分别用小鼠进行镇静和镇痛实验。结果：天麻超微粉不但在镇静作用方面与普通粉有差异，而且在镇痛作用方面也有差异。结论：天麻超微粉和普通粉对小鼠自主活动有一定的抑制作用，可明显延长小鼠的睡眠持续时间和减少小鼠扭体次数，且天麻超微粉所用剂量较低；热板法镇痛实验显示天麻超微粉明显提高小鼠痛阈值，天麻普通粉作用不明显。

Tranquil and analgesic studies on different particle diameters of Gastrodia elata BL.

OBJECTIVE:To compare pharmacodynamics of extremly fine powder with that of ordinary powder for Gastrodia elata BL. METHOD:Gastrodia elata BL. of the same batch was pulverized into extremly fine and ordinary powder by cellular level and ordinary pulverizer respectively. Tranquil and analgesic studies of them were performed on mice respectively. RESULTS:There was a definite difference of tranquil and analgesic effect between extremly fine and ordinary powder of Gastrodia elata BL. CONCLUSION:Independent activities of mice could be inhibited to a certain extent with significantly extending dormant duration and decreasing twisting times, by both extremly fine and ordinary powder of Gastrodia elata BL, while the dosage of extremly fine powder could be used lower than the other one; analgesic experiments of hot plate method indicated, rather than ordinary powder, the analgesic threshold of mice could be significantly elevated by taking extremly fine powder of Gastrodia elata BL.