Synergistic anti-tumor effect of recombinant human endostatin adenovirus combined with gemcitabine |
| |
Authors: | Wu Yang Yang Li Hu Bing Liu Ji-Yan Su Jing-Mei Luo Yan Ding Zhen-Yu Niu Ting Li Qiu Xie Xing-Jiang Wen Yan-Jun Tian Ling Kan Bing Mao Yong-Qiu Wei Yu-Quan |
| |
Institution: | State Key Laboratory of Biotherapy for Human Diseases, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PRC. |
| |
Abstract: | Endostatin is an important endogenous inhibitor of neovascularization, which has been widely used in anti-angiogenesis therapy for cancer. To fully explore the potential of endostatin, we evaluated the anti-tumor efficacy of the combination of recombinant human endostatin adenovirus and low-dose gemcitabine in nude mice. We injected recombinant human endostatin adenovirus intratumorally plus a low dose of gemcitabine i.p. routinely. The combination treatment produced no side-effects, and resulted in marked suppression in tumor formation and growth of established human lung carcinoma xenografts in nude mice, with decreased microvessel density and increased apoptosis percentage. Our data support the idea of synergistic anti-tumor properties of endostatin plus low-dose chemotherapy against human lung cancer in vivo. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|