Effects of ketamine on synaptic transmission in cat spinal cord.

Effects of ketamine on the evoked synaptic potentials and on the post-tetanic potentiation (PTP) of synaptic responses were studied in dorsal root-ventral root preparations of unanaesthetized spinal cats. Ketamine, in doses of 10–20 mg/kg, depressed the synaptic transmission, but enhanced the PTP responses in spinal cord. The enhancement of PTP responses after ketamine may be related to its seizure-inducing property.