奥克喷预防乳腺癌术后放射性皮肤损伤临床研究

目的 观察医用射线防护剂奥克喷局部外用对乳腺癌根治术后放疗引起的放射性皮肤损伤的防治作用.方法 将接受直线加速器放射治疗的乳腺癌患者随机分组：实验组、对照组各40例,实验组患者于放疗前及临睡前对照射区皮肤采用奥克喷外喷;对照组患者给予常规皮肤护理及健康教育,未采用特殊保护措施.以胸壁出现的放疗反应及用药后的变化作为观察指标,比较两组患者放射性皮肤损伤的发生率.结果 实验组放射性皮肤损伤的发生率明显低于对照组,差异无统计学意义（P＜0.05）.结论 奥克喷局部应用能推迟皮肤反应发生的时间,提高皮肤辐射的耐受性,有效防治乳腺癌根治术后患者放疗引起的皮肤放射性损伤.

The Clinical Research of the Prevention Effect of Oak Spray Against Radiation-induced Skin Injury from Postoperative Radiotherapy for Breast Cancer Patients

Objective To observe the protective effect of Oak spray on radiation - induced skin injury from postoperative radiotherapy for breast cancer patients. Methods The breast cancer patients who accepted linear accelerator radiotherapy were randomly grouped into experimental group and control group, each consisting of 40 members. The patients in the experimental group were treated with Oak spray in their radiated skin area before radiotherapy and going to sleep; while the patients in the control group were treated with conventional skin care methods and health education instead of any special protective measures. The reaction after radiotherapy and change after using Oak spray were adopted as observation indexes to compare the incidence of radiation - induced skin injury between the patients in the two groups. Result The incidence of radiation - induced skin injury in the experimental group was significantly lower than that in the control group with the statistical significance（P 〈 0.05）. Conclusion The application of Oak spray will delay the occurrence of skin reaction, improve the skin＇ s tolerance to radiation, and effectively protect the breast caneer patients against radiation - induced skin injury from postoperative radiotherapy.