Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis |
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Authors: | Derek Holmes Qi Jiang Liguo Zhang Lishan Su |
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Institution: | (1) Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA |
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Abstract: | FoxP3+CD4+CD25+ regulatory T (Treg) cells are implicated in a number of pathologic processes including elevated levels in cancers and infectious
diseases, and reduced levels in autoimmune diseases. Treg cells are activated to modulate immune responses to avoid over-reactive
immunity. However, conflicting findings are reported regarding relative levels of Treg cells during HIV-1 infection and disease
progression. The role of Treg cells in HIV-1 diseases (aberrant immune activation) is poorly understood due to lack of a
robust model. We summarize here the regulation and function of Foxp3 in Treg cells and in modulating HIV-1 replication.
Based on recent findings from SIV/monkey and HIV/humanized mouse models, a model of the dual role of Treg cells in HIV-1 infection
and immuno-pathogenesis is discussed. |
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Keywords: | Regulatory T cells AIDS Chromatin Epigenetic Humanized mouse DKO-hu ONTAK |
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