天门冬氨酸转氨酶同工酶测定对心、肝疾病诊断的临床意义

目的通过对心、肝疾病患者血清线粒体天门冬氨酸转氨酶（mitochondrial aspartate aminotransferase,m-AST）的测定,探讨其在心、肝疾病诊断中的价值。方法采用免疫抑制法测定56例心脏疾病和118例肝脏疾病患者血清m-AST活性。结果心肌病组m-AST水平显著高于正常对照组,差异有统计学意义（P〈0.01）,心肌梗死组差别最显著;肝脏疾病组与正常对照组比较,急性肝炎、慢性中度、重度肝炎m-AST显著高于对照组,差异有统计学意义（P〈0.01）;而肝硬化、原发性肝癌患者中仅有轻度增高。结论血清m-AST的测定是心、肝疾病良好的辅助诊断指标之一。

Clinical ralue of mitochondrial aspartate aminotransferase in diagnosing cardiac and hepatic diceases

Objective To study the clinical value of mitochondrial aspartate aminotransferase(m-AST)in cardiac and hepatic diseases.Methods The serum m-AST activity in 56 heart disease patients and 118 liver disease patients were measured by immunity inhibition methods.Results The m-AST activity of myocardiosis patients was significantly higher than that of the normal control group(P<0.01).Most significant difference was found in myocardial infarction group.The m-AST activity of acute hepatitis,nroderate and severe chronic hepatitis patients was also significantly higher than that of the normal control group(P<0.01)but only increased slightly in cirrhosis and liver cancer patients.Conclusion The serum m-AST activity is a good assistant diagnosis index to heart and liver diseases.