血清二肽基肽酶4与2型糖尿病患者体脂含量及分布的关系探讨

目的 探讨2型糖尿病（T2DM）患者血清二肽基肽酶4（DPP-Ⅳ）水平与体脂含量及分布的关系.方法 选取2013年7月至11月入住云南省第一人民医院内分泌科的T2DM患者共40例为研究对象,测量其身高、体重,计算体质指数（BMI）;电化学发光法测定总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）;酶联免疫法测定DPP-Ⅳ水平;双能X线骨密度分析仪（DEXA）测定体脂及瘦肉组织含量.将所有患者分为：体重正常组（NC组）14例（BMI 18.5～24.0 kg/m^2）,超重/肥胖组（OB组）26例（BMI≥24.0 kg/m2）.组间比较采用t检验,相关性分析采用Spearman法.结果 与NC组比较,OB组血清DPP-Ⅳ水平显著升高[（765±72）比（706±91） μg/L,t=2.2480,P＜0.05].血清DPP-Ⅳ水平与全身脂肪含量（FAT）之间呈正相关（r=0.498,P＜0.05）.血清DPP-Ⅳ水平与T2DM患者躯干脂肪含量、上肢脂肪含量及下肢脂肪含量呈正相关（r=0.567、0.391、0.344,均P＜0.05）,与全身及各部位瘦肉组织含量无相关关系.结论 血清DPP-Ⅳ水平可能与T2DM患者体脂含量及分布相关.

Investigation of serum dipeptidyl peptidase-4, body fat content and distribution in type 2 diabetes

Objective To investigate the relationship between serum dipeptidyl peptidase 4 （DPP-Ⅳ） and body fat content and distribution in type 2 diabetes （T2DM）.Methods A total of 40 T2DM inpatients treated in Department of Endocrinology of the First People＇s Hospital of Yunnan Province from July 2013 to November 2013 were enrolled.The height,weight,body mass index （BMI） were measured; total cholesterol（TC）,triglyceride（TG）,low density lipoprotein cholesterol （LDL-C） were detected by electrochemiluminescence assay and serum DPP-Ⅳ were detected by enzyme linked immunosorbent assay （Ray Biotech）.Body fat content and lean mass was measured by dual energy X-ray （DEXA）.Based on BMI,the subjects were divided into 2 groups：the normal weight group （BMI 18.5-24.0 kg/m^2,NC group,n=14） and the over weight/obese group （BMI≥24.0 kg/m^2,OB group,n=26）.Two-tailed independent samples t test was used for comparison of normally distributed measurement data between groups.Spearman correlation coefficient was used for correlation analysis.Results Compared with NC group,the level of DPP-Ⅳ in OB group was significantly higher （（765±72）vs （706±91）μμg/L,t=2.2480,P〈0.05）.The level of serum DPP-Ⅳ was positively correlated with body fat content （FAT,r=0.498,P〈0.05）.The level of DPP-Ⅳ was positively correlated with trunk fat content,arm fat content and thigh fat content （r=0.567,0.391,0.344,respectively,all P〈0.05）.There was no significant correlation between the level of DPP-Ⅳ and lean body mass.Conclusion The level of serum DPP-Ⅳ may be correlated with body fat content and distribution in T2DM.