龋病与口腔白色念珠菌家族传播的相关性研究

目的探讨龋病与口腔白色念珠菌家族传播的关系。方法2007年10月至2008年3月间采集35个家庭(119个样本)口腔牙菌斑,用多聚酶链式反应(PCR)检测白色念珠菌基因型,并记录龋失补(DMFT)指数。结果18个家庭(18/35,51.4%)、34个样本(34/119,28.6%)中检出白色念珠菌,其中11个家庭存在家族传播(11/18,61.1%)。呈垂直传播、垂直-水平传播和水平传播的白色念珠菌基因型一致率分别为0(0/5),66.7%(2/3),66.7%(2/3),差异有统计学意义(x2=26.571,P<0.01)。念珠菌感染与DMFT指数无显著相关(P>0.05)。结论口腔白色念珠菌的传播呈明显的基因多态性,念珠菌感染与龋病无显著相关。

Dental caries and familial transmission of oral Candida albicans

Dental caries and familial transmission of oral Candida albicans. WU Fei，GONG Yan-bing, ZHANG Zhong-lin, WANG Mei-hui，JIANG Yong，ZHENG Jian-ling. Vocational Technology College of Liaoning Univercity of Traditional Chinese Medicine, Shenyang 110101, China Abstract： Objective To explore the relationship between dental caries and the familial transmission of oral Candida albicans. Methods A total of 35 families (119 samples) dental plaque samples were collected. PCR ITS1-ITS2 method was preformed for identification of Candida albicans genotype. Analyze familial transmission and DMFT. Results A total of 34 samples(34／119，28.6%)in 18 families (18／35，51.4%) were found to be Candida albicans carriers, 11 families（11／18，61.1%） showed familial transmission. The similar rate of Candida albicans genotypes in family was 0（0／5）in vertical transmission（mother／father to baby），66.7%（2／3）in vertical-horizontal transmission，66.7%（2／3） in horizontal transmission. The difference was statistically significant in Candida albicans genetype morphology of family transmission （x2 = 26.571, P<0.01）. The correlation between Candida albicans infection and dental caries was not statistically significant. Conclusion Candida albicans genotype shows significant polymorphism in familial transmission. The correlation between Candida albicans infection and dental caries is not statistically significant.