| 糖尿病肾病与丝裂原活化蛋白激酶信号级联反应的相关性研究 |
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| 引用本文： | 王欣,郑祥雄. 糖尿病肾病与丝裂原活化蛋白激酶信号级联反应的相关性研究[J]. 医学综述, 2008, 14(10): 1537-1540 |
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| 作者姓名： | 王欣 郑祥雄 |
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| 作者单位： | 1. 福建医科大学协和临床医学院,福州,350001
2. 福建医科大学附属协和医院肾内科福州350001 |
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| 摘 要： | 糖尿病肾病是导致终末期肾病的主要原因。丝裂原活化蛋白激酶(MAPK)信号通路,广泛存在各种真核细胞中,可将胞外刺激信号传递给胞核,是细胞应激和损伤反应的主要信号通路。该通路在糖尿病时被激活,与糖尿病肾病发病机制密切相关,本文就近年来该通路与糖尿病肾病(DN)关系的研究进展予以综述。
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| 关 键 词： | 信号转导 丝裂原活化蛋白激酶 糖尿病肾病 高糖 |
| 文章编号： | 1006-2084(2008)10-1537-04 |
| 修稿时间： | 2008-01-23 |
The Study of the Lorrelatim Between Diabetic Nephropathy And MAPK Pathway |
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| WANG Xin,ZHENG Xiang-xiong. The Study of the Lorrelatim Between Diabetic Nephropathy And MAPK Pathway[J]. Medical Recapitulate, 2008, 14(10): 1537-1540 |
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| Authors: | WANG Xin ZHENG Xiang-xiong |
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| Affiliation: | WANG Xin1,ZHENG Xiang-xiong2.(1.Union Clinical Medical College,Fujian Medical University,Fuzhou 350004,China,2.Department of Nephrology,Union Hospital,Fuzhou 350001,China) |
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| Abstract: | Diabetic nephropathy is a main cause of end-stage renal disease (ESRD).Mitogen activated protein kinase(MAPK)is wide spread in all of eucells and responsible for transfering some ecto-signs into cellular nucleus.It is a major signal of cell stress and cell injury.MAPK is activated in diabetic nephropathy.It is considered to be related to the pathogenesis.The article reviews the progress of the relation. |
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| Keywords: | Signal transduction Mitogen activated protein kinase Diabetic nephropathy High glucose |
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