| 蒿甲醚缓释片在狗体内的药代动力学 |
| |
| 引用本文： | 张志荣,胡海燕,洪诤,邱加闽,何金戈,黄民贵. 蒿甲醚缓释片在狗体内的药代动力学[J]. 华西药学杂志, 2000, 15(5): 335-337 |
| |
| 作者姓名： | 张志荣 胡海燕 洪诤 邱加闽 何金戈 黄民贵 |
| |
| 作者单位： | 华西医科大学药学院!四川成都610041(张志荣，洪诤)，中山大学药学系!广东广州510275(胡海燕)，四川省寄生虫病防治研究所!四川成都610041(邱加闽，何金戈，黄民贵) |
| |
| 摘 要： | 目的:建立狗血浆中蒿甲醚的含量测定法，并进行蒿甲醚缓释片狗体内药代动力学研究。方法:用3p87药代动力学程序计算蒿甲醚普通片及缓释片的药代动力学参数。结果:方法最低检测浓度0.02 μg.ml-1，线性范围0.05～12.5 μg.ml-1，r=0.994，方法回收率103.3%。蒿甲醚缓释片的AUC、Tmax、MRT、T1／2与普通片存在显著性差异。结论:缓释片与普通片比较具有缓效的特征。
|
| 关 键 词： | 毛细管气相色谱法 蒿甲醚缓释片 药代动力学 |
| 修稿时间： | 2000-05-01 |
PHARMACOKINETICS OF DELAYED-RELEASE ARTEMETHER TABLET IN DOGS |
| |
| ZHANG Zhi rong ,HU Hai yan ,HONG Zheng ,QIU Jia min ,HE Jin ge ,HUANG Min gui .School of Pharmacy,West China University of Medical Sciences,Chengdu China. PHARMACOKINETICS OF DELAYED-RELEASE ARTEMETHER TABLET IN DOGS[J]. West China Journal of Pharmaceutical Sciences, 2000, 15(5): 335-337 |
| |
| Authors: | ZHANG Zhi rong HU Hai yan HONG Zheng QIU Jia min HE Jin ge HUANG Min gui .School of Pharmacy West China University of Medical Sciences Chengdu China |
| |
| Affiliation: | ZHANG Zhi rong 1,HU Hai yan 2,HONG Zheng 1,QIU Jia min 3,HE Jin ge 3,HUANG Min gui 3 1.School of Pharmacy,West China University of Medical Sciences,Chengdu 610041 China, 2.Department of Pharmacy,Zhongshan University,Guang zhou 510275 China, |
| |
| Abstract: | Developing a method for assaying artemether in dog plasma,the pharmacokinentics of delayed-release artemether tablet in dogs was investigated.METHODS:Pharmacokinetics parameter of artemether tablet was calculated by 3p87 pharmacokinetics procedure.RESULTS:Lowest detectable concentration 0.2 μg.ml-1;linear range 0.05～12.5 μg.ml-1，r=0.994；method recovery 103.3%;AUC、Tmax、MRT、t1／2 of delayed-release artemether tablet had significant difference with conventional tablet(P<0.01).CONCLUSION:Delayed-release character of delayed-release Artemether tablet was significant. |
| |
| Keywords: | Capillary column gas chromatography Delayed release artemether tablet Pharmacokinetics Dogs |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
