| Expression of Plasmacytoid Dendritic Cells, IRF-7, IFN-α mRNA in the Lesions of Psoriasis Vulgaris |
| |
| 引用本文： | 陈静,谭志建,刘厚君,刘志香,吴艳,李家文.Expression of Plasmacytoid Dendritic Cells, IRF-7, IFN-α mRNA in the Lesions of Psoriasis Vulgaris[J].华中科技大学学报(医学英德文版),2006,26(6):747-749. |
| |
| 作者姓名： | 陈静 谭志建 刘厚君 刘志香 吴艳 李家文 |
| |
| 作者单位： | Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China |
| |
| 摘 要： | Psoriasis is a common and chronic inflammatory skin disease associated with both genetic and environ-mental risk factors. Recent researches have focused pri-marily on the role of innate immunity in psoriasis. Type Ⅰ interferons (IFNs), as represented by IFN-α, are promptly secreted upon the interaction between micro-bial pathogens and the immune system, and activate a variety of immune effector cells that belong to the innate as well as the adaptive immune system. Plasmacytoid dendritic ce…
|
| 关 键 词： | psoriasis pDCs IRF-7mRNA IFN-α mRNA |
| 收稿时间： | 2006-10-20 |
| 修稿时间： | 2006-10-20 |
Expression of plasmacytoid dendritic cells, IRF-7, IFN-α mRNA in the lesions of psoriasis vulgaris |
| |
| Jing Chen,Zhijian Tan,Houjun Liu,Zhixiang Liu,Yan Wu,Jiawen Li.Expression of plasmacytoid dendritic cells, IRF-7, IFN-α mRNA in the lesions of psoriasis vulgaris[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(6):747-749. |
| |
| Authors: | Jing Chen Zhijian Tan Houjun Liu Zhixiang Liu Yan Wu Jiawen Li |
| |
| Institution: | (1) Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China |
| |
| Abstract: | Summary To investigate the expression of plasmacytoid dendritic cells (pDCs), interferon regulatory factor-7 (IRF-7) and interferon
alpha (IFN-α) mRNA in skin lesions of patients with psoriasis vulgaris, the expressions of plasmacytoid dendritic cells, IRF-7,
IFN-α mRNA in the lesional skin of psoriasis vulgaris were detected by immunohistochemical technique (SP) and RT-PCR. Normal
skin of healthy volunteers, serving as control, was also tested. The immunohistochemical study showed that the expression
of pDCs in the psoriatic lesions was significantly higher than that in the normal controls. RT-PCR showed that the mRNA expression
of IRF-7 was much higher than that in normal controls, but no difference in the expression of IFN-α mRNA was found between
two groups. Our findings indicate that up-regulated expression of pDCs, IRF-7mRNA might be involved in the pathogenesis of
psoriasis. |
| |
| Keywords: | psoriasis pDCs IRF-7mRNA IFN-α mRNA |
| 本文献已被 CNKI 维普 SpringerLink 等数据库收录！ |
|
