首页 | 本学科首页   官方微博 | 高级检索  
检索        

电针对非酒精性脂肪肝大鼠胰岛素抵抗的影响
引用本文:冯雯琪,曾志华,卓廉士.电针对非酒精性脂肪肝大鼠胰岛素抵抗的影响[J].针刺研究,2008,33(2):111-115.
作者姓名:冯雯琪  曾志华  卓廉士
作者单位:重庆医科大学中医药学院,重庆,400050
摘    要:目的:探讨针刺治疗脂肪肝的机制。方法:33只雄性SD大鼠随机分为正常对照组(11只)、模型组(12只)和电针治疗组(10只)。以高脂饲料饲养8周建立非酒精性脂肪肝(NAFLD)大鼠模型,8周末,处死其中3只(正常对照组1只,NAFLD组2只),以验证造模成功。电针治疗组施以电针治疗,取"足三里"丰隆"三阴交"太冲"穴(疏密波,频率2 Hz,强度4 mA),每次15 min,连续治疗4周。12周末处死所有动物,用比色法检测血糖、血清游离脂肪酸含量,用放射免疫法测定血清胰岛素含量,计算稳态模式胰岛素抵抗指数、肝指数及HE染色观察大鼠肝组织病理学改变。结果:与正常对照组比较,NAFLD组大鼠的血糖、血清胰岛素、血清游离脂肪酸、胰岛素抵抗指数、肝指数指标均升高(P<0.05),肝脏中出现中重度弥漫性脂肪变性,尚可见肝细胞水肿等现象;电针治疗组上述5项指标均显著低于NAFLD组(P<0.05),其肝脂肪变性程度亦显著减轻。结论:针刺治疗可以通过改善胰岛素抵抗状态治疗NAFLD。

关 键 词:非酒精性脂肪肝  胰岛素抵抗  针刺
文章编号:1000-0607(2008)02-0111-05
修稿时间:2007年6月28日

Influence of Electroacupuncture on Insulin-resistanee in Nonalcoholic Fatty Liver Rats
FENG Wen-qi,ZENG Zhi-hua,ZHUO Lian-shi.Influence of Electroacupuncture on Insulin-resistanee in Nonalcoholic Fatty Liver Rats[J].Acupuncture Research,2008,33(2):111-115.
Authors:FENG Wen-qi  ZENG Zhi-hua  ZHUO Lian-shi
Institution:School of Chinese Medicine, Chongqing Medical University, Chongqing 400050, China.
Abstract:OBJECTIVE: To investigate the mechanism of electroacupuncture (EA) in treating nonalcoholic fatty liver disease (NAFLD) in rats. METHODS: Thirty male SD rats were randomized into normal control, NAFLD model and EA groups, with 10 cases in each. NAFLD model was established by feeding the rats with high-fat food for 8 weeks. EA (2 Hz, 4 mA) was applied to "Zusanli" (ST 36), "Fenglong" (ST 40), "Sanyinjiao" (SP 6), and "Taichong" (LR 3) for 15 min, once daily for 4 weeks. Fasting blood sugar (FBG) and serum free fatty acids (FFA) were detected with chromatometry; serum insulin (INS) was determined with radioimmunoassay; homeostasis model assessment insulin resistance (HOMA-IR) and liver index (LI) were calculated. Liver tissue was cut into sections for detecting pathological changes. RESULTS: Compared with normal control group, FBG, INS, FFA, HOMA-IR and LI of model group increased significantly (P<0.05), and hepatic diffuse steatosis with cellular necrosis and inflammatory cell infiltration was obvious. In comparison with model group, all the 5 indexes in EA group decreased significantly (P<0.05), and pathological changes as hepatic steatosis, etc. were significantly reduced. CONCLUSION: EA may be used to effectively improve NAFLD by lowering insulin resistance.
Keywords:Nonalcoholic fatty liver  Insulin resistance  Electroacupuncture
本文献已被 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号