血清胆红素及尿酸水平与冠心病的相关性研究

目的探讨血清胆红素及尿酸水平与冠心病之间的关系。方法经选择性冠状动脉造影确诊为冠心病的225例患者作为冠心病组,同期行冠状动脉造影后排除冠心病的206例患者作为对照组,入选者均检测血清总胆红素、直接胆红素、间接胆红素、尿酸及血脂水平,并进行比较分析。结果与对照组比较,冠心病组患者总胆红素、直接胆红素和间接胆红素水平明显下降(11.16±2.12)μmol/L比(16.45±2.36)μmol/L,(2.53±1.21)μmol/L比(3.35±2.11)μmol/L,(7.63±2.48)μmol/L比(9.52±3.27)μmol/L],尿酸、总胆固醇、三酰甘油和低密度脂蛋白胆固醇水平明显升高(369.82±95.62)μmol/L比(302.69±72.53)μmol/L,(5.13±1.48)mmol/L比(4.35±1.32)mmol/L,(1.65±0.23)mmol/L比(1.12±0.17)mmol/L,(3.26±1.24)mmol/L比(2.59±1.06)mmol/L],差异均有统计学意义(均为P<0.01)。结论血清胆红素水平的降低和尿酸水平的升高与冠心病发生相关。

Correlation of serum levels of bilirubin and uric acid with coronary heart disease

Objective To study the correlation of serum levels of bilirubin and uric acid with coronary heart disease. Methods According to the results of coronary angiography, 225 patients with coronary heart disease were enrolled as CHD group, and another 206 non-CHD subjects as control group. Serum levels of total bilirubin, direct bilirubin, indirect bilirubin, uric acid and blood lipids were measured, compared and analyzed among all groups. Results Compared with control group, serum levels of total bilirubin, direct and indirect bilirubin were significantly decreased （11.16 ±2. 12） μmolfL vs. （16.45 ± 2. 36） μmol/L, （ 2. 53 ± 1.21 ） μmol/L vs. （ 3.35 ± 2. 1 1 ） μmol/L and （ 7. 63 ± 2. 48 ） μmol/L vs. （9. 52 ±3.27） μmol/L, respectively, all P 〈 0. 01 ], and serum uric acid, total cholesterol, triglyceride and low density lipoprotein-eholesterol significantly increased （ 369. 82 ± 95.62） μ mol/L vs. （ 302.69 ± 72. 53） μmol/L, （5. 13 ± 1.48） mmol/L vs. （4. 35 ± 1.32） mmol/L, （ 1.65 _±0. 23） mmol/L vs. （ 1.12 ±0. 17） mmol/L and （3.26 ± 1.24） mmol/L vs. （2. 59 ± 1.06） retool/L, respectively, all P 〈0. 01 ] in CHD group. Condusions Decrease of serum bilirubin level and increase of serum uric acid level are related to occurrence of coronary heart disease.