+Gz 重复暴露对大鼠血小板粘附、聚集和血流变的影响

目的 探讨＋Gz重复暴露后，大鼠血小板计数（PLT）、粘附试验（PAdT)、聚集试验（PAgT)和血液流变学的变化。方法 利用动物离心机，将大鼠分别重复暴露＋10Gz 20s、＋10Gz 40s，共作用4次，两次之间间歇5min。观察＋Gz暴露后，PLT、PAdT、PAgT和血液流变学的变化。结果 ＋10Gz 40s组与对照组相比，PLT、PAdT和PAgT都明显增加（P＜0．05或P＜0．01）；全血粘度（ηb)、全血还原粘度（ηrd)和红细胞聚集指数（EAI）亦增加，差异均有显著性意义（P＜0．05）。＋10Gz 20s与对照组相比，各参数无明显变化。结论 ＋10Gz 40s重复暴露可引起血小板粘附、聚集功能增强和血液流变学的改变，而20s的10Gz暴露则不引起这些变化。

Effect of repeated +Gz exposures on platelet adhesiveness, aggregation and hemorheology in rats

Objective To investigate the changes of platelet count (PLT), platelet adhesiveness(PAdT), platelet aggregation (PAgT) and hemorheology in rats after repeated +G z exposures. Methods Twenty four SD rats served as subjects. They were randomly divided into control group and 2 experimental groups, which underwent repeated (4 times)+10 G z 20 s and +10 G z 40 s respectively with 5 min interval in between 2 exposures. PLT, PAdT, PAgT and hemorheology were measured after repeated +G z exposures. Results Compared with those of control group the PLT, PAdT and PAgT of +10 G z 40 s group were significantly higher (P<0.05 or P<0.01); and the hemorheology indexes also showed significant changes, while in +10 G z 20 s group the changes of these indexes were non-significant. Conclusion The repeated +10 G z 40 s exposures can induce changes of PLT, PAdT, PAgT and hemorheological indexes in rats, while repeated +10 G z 20 s exposures can't.