体质量对反流性食管炎患者下食管括约肌压力和24h食管pH监测结果的影响

目的探讨反流性食管炎（RE）患者中，体质量对下食管括约肌压力（LESP）和24h食管pH监测结果的影响。方法对18例体质量正常RE患者和22例超重肥胖RE患者进行LESP和24h食管pH监测，对结果进行统计分析。结果超重肥胖组RE患者的LESP、pH〈4总反流时问百分比、反流时间〉5min的反流次数、总反流数、DeMeester分与体质量正常组RE患者比较，差异均有统计学意义（P均〈0．05）；而超重肥胖组RE患者与体质量正常组RE患者的下食管括约肌松弛率（LESRR）比较，差异无统计学意义（P〉0．05）。结论在RE患者中，超重肥胖可影响食管动力并增加食管的酸暴露，控制体质量对治疗RE可能有一定作用。

Effect of body weight on low esophageal sphincter pressure and 24-hour esophageal pH monitoring inpatients with reflux esophagitis

Objective To explore the effect of body mass index (BMI) on low esophageal sphincter pressure (LESP) and 24-hour esophageal pH monitoring in patients with reflux esophagitis (RE). Methods The results of LESP and 24-hour esophageal pH monitoring were compared between 18 RE pa-tients with normal BMI and 22 RE patients with high BMI. Results There were significant differences be-tween 2 groups regarding LESP, time percentage of pH<4, long reflux episodes (>5 minutes), total reflux episodes and DeMeester score (P<0.05), while there was no significant difference between 2 groups in low esophageal sphincter relaxation rate (P>0.05). Conclusion Overweight and obesity may affect esophage-al motility and increase esophageal exposure to acid in RE patients, which warrents weight control in treat-ment of RE.