蒿甲醚联合双氢青蒿素哌喹治疗恶性疟疾47例

目的探讨输入性恶性疟疾的临床特征和治疗方案。方法回顾性分析47例恶性疟疾患者应用蒿甲醚和双氢青蒿素哌喹联合治疗的临床资料。结果应用蒿甲醚和双氢青蒿素哌喹联合治疗临床治愈率为97.9%,死亡1例（2.1%）。多数患者给药前后存在头昏、头痛、恶心、纳差、全身无力以及肢体酸痛等症状,可能与药物应用无关。46例存活患者临床症状消失时间为1～5d,联合治疗结束后连续3次血涂片检查疟原虫阴性。结论蒿甲醚和双氢青蒿素哌喹联合治疗疟疾临床疗效显著,副作用少,值得推广。

47 cases of malignant malaria receiving combination therapy of Artemether and Dihydroartemisinin/Piperaquine Phosphate

Objective To explore the clinical characteristics and treatment of patients with malignant malaria. Method Forty seven imported cases of malignant malaria receiving combination therapy of Artemether and Dihydroartemisinin/ Piperaquine Phosphate were reviewed. Results 97.9% of patients were successfully treated with the combination therapy of Artemether and Dihydroartemisinin/Piperaquine Phosphate. One subject （2.1%） died of the treatment. The main clinical characteristics of the patients were fever, headache, aching pain in muscle and joints, and fatigue. The clinical performance was complex. Conclusion Combination therapy with Artemether and Dihydroartemisinin/Piperaquine Phosphate shows high efficacy and low side effect in the patients.