前列腺孤立性纤维肿瘤临床病理观察

目的探讨前列腺孤立性纤维肿瘤的临床表现、病理形态学、免疫组化及鉴别诊断。方法收集前列腺孤立性纤维肿瘤10例,观察其临床病理特点及免疫组化表型。结果年龄46～85岁。光学显微镜下形态多样,边界清晰,由交替性分布的细胞丰富区和细胞稀疏区组成,分枝状的血管外皮瘤样结构;可见黏液变、脂肪细胞形成。免疫表型:几乎所有肿瘤细胞质呈Viment(10/10)、CD34(10/10)强阳性、弥漫表达,CD99(9/10)、Bcl-2(10/10)呈阳性表达。结论孤立性纤维肿瘤可发生在躯体所有解剖部位,发生在前列腺的孤立性纤维肿瘤需与该处其他梭形细胞肿瘤鉴别,依据其组织学特点及免疫组化表型可作出诊断。

Clinicopathology observation of solitary fibrous tumors of prostate

Objective To investigate the clinical manifestation,pathological morphology,immunohistochemical features and differential diagnosis of the prostate solitary fibrous tumors(PSFT).Methods PSFT in 10 cases were collected to observe their clinical features and immunohistochemical phenotype.Results The age ranged from 46 to 85 years.Histologically,the tumors showed range of growth cellular and patterns,varied from predominantly fibrous lesions containing large collagenized areas to more cellular and less fibrous areas,with thick-walled branching vessels showing HPC-like growth pattern.Myxoid degeneration and fat-forming areas were noted immunohistochemically.Immunophenotype: all cases of the tumor cells showed diffusely and strongly positives for both Vimentin(10/10) and CD34(10/10),less frequently positive for CD99(9/10),Bcl-2(10/10).Conclusion SFT are mesenchymal spindle cell tumors which could be found in various sites of human body and need to be distinguished from spindle cell tumors according to the histological characteristics and immunohistochemical phenotype.