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| 中药调节肾脏细胞信号通路机制的研究进展 | |
| 引用本文： | 王朝俊,万毅刚,罗浔阳,窦晨辉,冯青,严巧婧,姚建.中药调节肾脏细胞信号通路机制的研究进展[J].中国中药杂志,2011,36(1):85-91. |
| 作者姓名： | 王朝俊 万毅刚 罗浔阳 窦晨辉 冯青 严巧婧 姚建 |
| 作者单位： | 1. 南京中医药大学,中西医结合鼓楼临床医学院,江苏,南京,210008 2. 南京大学,医学院附属鼓楼医院,江苏,南京,210008 3. 郑州人民医院,河南,郑州,450000 4. 日本山梨大学,研究生院,医学工学综合研究部,分子信号教研室,日本,甲府市,409-3898 |
| 基金项目： | 南京市医学科技发展项目(YKK08058) |
| 摘 要： | 肾脏细胞的增殖、分化和凋亡以及相关细胞因子、炎症介质的表达都与细胞信号通路有密切的关系.这些信号通路包括酪氨酸激酶通路、转化生长因子-β/Smaad通路、Rho/Rho相关卷曲螺旋形成蛋白激酶通路、肌醇磷脂通路、环核苷酸 '通路、核因子kB通路等.单味中药及其提取物(如大黄、雷公藤甲素等)和一些中药复方(如黄芪当归合剂、柴苓汤等)不仅可以通过调节细胞信号通路而改善肾脏细胞的增殖、分化和凋亡,而且,还可以通过干预信号通路中关键信号分子的磷酸化过程,从而调控靶基因的转录、表达以及相应的生物学效应. |
| 关 键 词： | 中药 肾脏 细胞信号通路 |
| 收稿时间： | 2010/8/21 0:00:00 |
Regulative mechanism of Chinese herbal medicine on cell signaling pathway in kidney |
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| WANG Chaojun,WAN Yigang,LUO Xunyang,DOU Chenhui,FENG Qing,YAN Qiaojing and YAO Jian.Regulative mechanism of Chinese herbal medicine on cell signaling pathway in kidney[J].China Journal of Chinese Materia Medica,2011,36(1):85-91. | |
| Authors: | WANG Chaojun WAN Yigang LUO Xunyang DOU Chenhui FENG Qing YAN Qiaojing and YAO Jian |
| Institution: | Nanjing Drum Tower Hospital Clinical College of Traditional Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Zhengzhou People's Hospital, Zhengzhou 450000, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China;Department of Molecular Signaling Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, 409-3898, Japan;Department of Molecular Signaling Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, 409-3898, Japan |
| Abstract: | |
| Keywords: | Chinese herbal medicine kidney cell signaling pathway |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |