| 乙酰半胱氨酸及氢化可的松对重症急性胰腺炎治疗作用的实验研究 |
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| 引用本文： | 蔡笃雄,陈卫昌,曾仕平,汤净,林尤冠.乙酰半胱氨酸及氢化可的松对重症急性胰腺炎治疗作用的实验研究[J].重庆医学,2010,39(2). |
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| 作者姓名： | 蔡笃雄 陈卫昌 曾仕平 汤净 林尤冠 |
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| 作者单位： | 海南医学院附属医院消化内科,海口,570102;苏州大学附属第一医院消化内科,苏州,215006 |
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| 摘 要： | 目的探讨N-乙酰半胱氨酸(NAC)及氢化可的松对重症急性胰腺炎(SAP)的治疗保护作用及作用机制。方法72只SD大鼠随机分为4个组,假手术(SO)组、SAP组、NAC处理组及氢化可的松治疗组。采用胰胆管逆行注射5%牛磺胆酸钠诱导大鼠SAP模型;NAC处理组于模型制作前30min腹腔内注射NAC(200mg/kg)进行预处理;氢化可的松治疗组于SAP模型制作成功后10min给予舌下静脉注射氢化可的松琥珀酸钠(10mg/kg);假手术(SO)组开腹后仅翻动胰腺,即关腹。分别观察各组大鼠血浆淀粉酶、TNF-αI、L-6、肺湿/干比值、胰腺及肺组织病理以及组织髓过氧化物酶(MPO)的变化,采用RT-PCR法检测肺组织TNF-αmRNA的表达。结果SAP组血浆淀粉酶、TNF-α、IL-6、肺湿/干比值、肺组织TNF-αmRNA的表达、胰腺及肺组织MPO均较SO组明显升高,差异有统计学意义(P<0.05),NAC处理组及氢化可的松治疗组上述各检测指标均较SAP组显著降低,差异有统计学意义(P<0.05),NAC处理组胰腺及肺组织病理损伤明显减轻,氢化可的松治疗组肺组织病理损伤较SAP组减轻。结论NAC及氢化可的松可通过减...
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| 关 键 词： | 胰腺炎 乙酰半胱氨酸 激素 细胞因子 |
An experimental study of therapeutic effect of antioxidant and cortisone on severe acute pancreatitis |
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| CAI Du-xiong,CHEN Wei-chang,ZENG Shi-ping,et al..An experimental study of therapeutic effect of antioxidant and cortisone on severe acute pancreatitis[J].Chongqing Medical Journal,2010,39(2). |
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| Authors: | CAI Du-xiong CHEN Wei-chang ZENG Shi-ping |
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| Institution: | 1.Department of Gastroenterology;Affiliated Hospital of Hainan Medical College;Haikou;Hainan 570102;China;2.Department of Gastroenterology;First Affiliated Hospital;Suzhou University;Suzhou;Jiangsu 215006;China |
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| Abstract: | Objective To investigate the therapeutic effect and mechanism of antioxidant and cortisone on severe acute pancreatitis(SAP).Methods Seventy-two SD rats were randomized into four groups:sham operation(SO)group,SAP group,N-acetylcysteine(NAC)-pretreated group and hydrocortisone-treated group.The model of SAP was induced by retrograde injection of 5% sodium taurocholate into the bile-pancreatic duct in SD rats,NAC-pretreated group was given 200mg/kg NAC intraperitoneally 30 min before inducing SAP,hydrocortis... |
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| Keywords: | pancreatitis N-Acetylcysteine Hydrocortisone cytokine |
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