The effects of capsaicin on the early outward current in identified snail neurones |
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Authors: | L Erdélyi G Such |
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Affiliation: | 1. Department of Comparative Physiology, Attila József University, H-6726 Szeged Hungary;2. Department of Physiology, Medical School, H-6726 Szeged Hungary |
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Abstract: | An investigation of the action of capsaicin (CAP) on the early outward current (IA) in identified neurones of Helix pomatia was performed using the single electrode clamp. CAP (60-300 microM) caused a dose-dependent reduction of the IA-currents in LPa3 and RPa3 neurones both in normal and Na-free solutions. There was also a marked shortening of the time constant for the inactivation of IA, and a 5-10 mV shift in the hyperpolarizing direction of the curve relating the steady-state inactivation of IA to membrane potential. The equilibrium potential for IA was not changed in up to 300 microM CAP solutions. |
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Keywords: | capsaicin snail neuron |
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