| Jab1在喉鳞状细胞癌中的表达及临床意义 |
| |
| 引用本文： | 张锋,曹华.Jab1在喉鳞状细胞癌中的表达及临床意义[J].山东医大基础医学院学报,2007(2). |
| |
| 作者姓名： | 张锋 曹华 |
| |
| 作者单位： | 郑州大学第一附属医院耳鼻咽喉科 河南郑州450052 |
| |
| 摘 要： | 目的:探讨Jab1在喉鳞状细胞癌(LSCC)中的表达及其与LSCC临床病理和预后的关系。方法:采用免疫组化SP法检测23例正常喉黏膜(NLT)和72例LSCC组织中Jab1的表达。结果:在54.17%的LSCC中Jab1呈现过表达,并且与临床分期和淋巴结转移呈显著正相关,与患者的总生存率呈负相关(P<0.05)。结论:Jab1可能通过调节p27kip1蛋白的降解而参与LSCC的发生、发展,Jab1可以作为LSCC的一个预后指标。
|
| 关 键 词： | 喉肿瘤 癌 鳞状细胞 免疫组织化学 Jab1 |
Expression of Jab1 in laryngeal squamous cell carcinoma |
| |
| ZHANG Feng,CAO Hua.Expression of Jab1 in laryngeal squamous cell carcinoma[J].Journal of Preclinical Medicine College of Shandong Medical University,2007(2). |
| |
| Authors: | ZHANG Feng CAO Hua |
| |
| Abstract: | Objective: To study the expression of Jab1(c-Jun activation domain-binding protein 1) in laryngeal squamous cell carcinoma(LSCC) and its correlation with clinicopathologic variables and prognosis.Methods: Expression of Jab1 protein was determined by SP immunohistochemistry in 23 cases of normal laryngeal tissues and 72 cases of LSCC.Results: Jab1 over-expression was produced in 54.17% of LSCC and was significantly positively associated with clinicopathologic variables and lymph node metastasis.Survival analysis revealed that Jab1 over-expression was significantly negatively associated with the overall survival(P<0.05).Conclusions: Jab1 protein may contribute to the development and progression of LSCC by facilitating the degradation of p27kip1 and represents a novel prognostic indicator for LSCC. |
| |
| Keywords: | Laryngeal neoplasms Carcinoma squamous cells Immunohistochemistry Jab1 |
| 本文献已被 CNKI 等数据库收录！ |
