含加替沙星的四联方案补救治疗幽门螺杆菌的临床观察

目的]分析含加替沙星的四联疗法补救初次根除治疗幽门螺杆菌(H.pylori,Hp)失败的有效性和安全性.方法]将133例Hp感染初次根除失败患者随机分为治疗组71例,对照组62例.治疗组给予加替沙星、呋喃唑酮、果胶铋、兰索拉唑治疗,对照组给予甲硝唑、呋喃唑酮、果胶铋、兰索拉唑治疗,疗程均为10 d.停药4周后复查Hp,分析Hp的根除率及不良反应发生率.结果]治疗组、对照组Hp根除率分别为91.18％、81.67％ (P＜0.05).不良反应发生率治疗组为13.23％,对照组为21.67％,2组间差异有统计学意义(P＜0.05).结论]含加替沙星的四联方案是治疗Hp初次根除失败后的一种安全、有效的补救治疗方案.

Clinical study of gatifloxacin-based quadruple regimen as a rescue therapy after failure of initial eradication therapy of Helicobacter pylori

Objective]To investigate the efficacy and safety of gatifloxacin-based quadruple regimen as a rescue therapy after failure of initial eradication therapy of H.pylori. Methods]A total of 133 H.pylori-positive patients with chronic gastritis who had a failed course of initial eradication therapy,were randomized to treatment group and control group.Treatment group were administered gatifloxacin(400mg,qd),furazolidone(0.1g,bid),Colloidal Bismuth Pectin(150mg,qid)and lansoprazole(30 mg,bid)for 10 days,while the control group received metronidazole(0.4g,bid),furazolidone(0.1g,bid),Colloidal Bismuth Pectin(150mg,qid)and lansoprazole(30 mg,bid)for 10 days.Four weeks later,the H.pylori eradication and side reaction were analysed. Results]The H.pylori eradication rates between the treatment group and the control group were 91.18% and 81.67% respectively,showing significant difference between each other(P<0.05).The side reaction rates between the two groups were 13.23% and 21.67% respectively,showing significant difference between each other(P<0.05). Conclusion]Gatifloxacin-based quadruple regimen is a safe and effective rescue therapy after a failed initial eradication therapy.