摄食行为对小型猪心脏自主神经功能的影响

目的 观察摄食行为对小型猪心脏自主神经功能的影响.方法 利用大动物无创遥测技术观察清醒活动状态下小型猪摄食前(BI)、摄食过程中(IP)、摄食后(AI)、AI2 h和AI 4h的心电图(ECG)和自主活动,并用HRV功率谱分析其自主神经功能.结果 与摄食前比较,小型猪摄食过程中心率(HR)、自主活动和标准化低频成分(LFnu)明显增加,RR间期(RRI)、总功率(TP)、极低频成分(VLF)、高频成分(HF)明显减少,LF/HF比值明显升高；且随着摄食后恢复时间的延长,小型猪HR、自主活动、LFnu均有所降低,而RRI、TP、VLF、HF均有所升高,LF/HF比值逐渐降低,并在摄食后2h、4h时变化显著；相关分析显示摄食行为与TP、VLF、HF、LF和LF/HF密切相关,多元线性逐步回归分析亦显示摄食行为与VLF、LF/HF和TP密切相关,且VLF起主要作用.结论 小型猪摄食行为不仅影响心脏活动；而且能引起小型猪心脏自主神经控制能力发生改变,其中VLF在摄食行为过程中占有重要作用.

Effect of Feeding Behavior on Autonomic Nervous Function of Heart in Miniature Swine

Objective To observe the effects of feeding behavior on autonomic nervous function of heart in miniature swine.Methods Electrocardiogram(ECG) and autonomic activities were recorded before,during and after ingestion 0h,2h and 4h,from conscious and unrestrained miniature swine using a non-invasive telemetry system and the autonomic nervous function was investigated by power spectral analysis of heart rate variability(HRV).Results Compared with before ingestion(BI),the Heart rate,autonomic activities and normalize low frequency(LFnu) power were obviously increased,R-R interval,total power(TP),very low frequency(VLF) power and high frequency(HF) power were significantly decreased,the LF to HF ratio was raised during ingestion(IP).After food,the HR,autonomic activities and LFnu were decreased,while RRI,TP,VLF and HF were increased and the LF to HF ratio was lowed,especially after ingestion for 2h and 4h.Correlation analysis showed that feeding behavior and TP,VLF,HF,LF and LF/HF were closely related,and the multivariate linear gradual regression analysis also showed that feeding behavior and the VLF,LF/HF and TP were closely related,and VLF played a major role in feeding behavior.Conclusion Feeding behavior was not only affected heart activity in miniature swine,but also could affect cardiac autonomic nervous control,which VLF played an important role in the process of feeding behavior.