丙泊酚与依托咪酯联合应用对卵巢癌化疗患者麻醉诱导时血流动力学的影响

目的观察丙泊酚与依托咪酯联合应用对卵巢癌化疗患者诱导插管期间血流动力学的影响。方法 30例接受术前化疗的卵巢癌患者随机分为3组每组10例患者：丙泊酚组（P组）、依托咪酯组（E组）、丙泊酚＋依托咪酯组（PE组）,观察诱导前（T0）、插管前1 min（T1）、插管后即刻（T2）、插管后1 min（T3）、2 min（T4）、5 min（T5）不同时点的血流动力学变化。结果与T0比较,P组T1～5MAP、HR明显降低（均P〈0.05）;E组T2～4MAP、HP明显增快（均P〈0.05）;PE组T1～5MAP、HR差别无统计学意义;3组患者T1～5时BIS值均显著降低（均P〈0.01）。结论麻醉诱导时,联合应用丙泊酚与依托咪酯可更好地维持卵巢癌术前化疗患者的血流动力学稳定。

Effects combined propofol and etomidate on hemodynamic change in ovarian cancer patients who accepted preoperative chemotherapy during induction of anesthesia

Objective To evaluate the effects of combined propofol and etomidate on hemodynamic response to tracheal intubation in ovarian cancer patients who accepted preoperative chemotherapy.Methods Thirty ovarian cancer patients who accepted preoperative chemotherapy were randomly divided into three groups(n=10,each) : Group P(propofol);Group E(etomidate);Group PE(propofol+etomidate).Hemodynamic parameters were evaluated at the point of before intubation(T0),1 min before intubation(T1),immediately after intubation(T2),at 1 min(T3),2 min(T4),5 min(T5) after intubation.Results Compared with the baseline at T0,MAP and HR were markedly decreased at T1-5 in group P while MAP and HR were obviously increased at T2-4 in group E.There was no significant difference in MAP and HR among these points in group PE.BIS were significantly lower after induction of anesthesia in all three groups.Conclusion Combined propofol and etomida may preferably maintain the stability of hemodynamics in ovarian cancer patients who accepted preoperative chemotherapy during induction of anesthesia