| 苄普地尔抗心律失常作用 |
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| 引用本文： | 谷淑玲,彭振云.苄普地尔抗心律失常作用[J].中国药理学通报,1992,8(4):285-287. |
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| 作者姓名： | 谷淑玲 彭振云 |
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| 作者单位： | 徐州医学院药理教研室 江苏221002
(谷淑玲，陈锦明，崔家勇)，徐州医学院化学教研室 江苏221002(彭振云) |
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| 摘 要： | 苄普地尔iv能明显提高乌头碱诱发大鼠心律失常用量及豚鼠心脏哇巴因中毒耐量;对BaCI_2、Adr诱发的实验性心律失常有明显对抗作用;对大鼠冠脉结扎复灌注引起的心律失常有保护作用。
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| 关 键 词： | 苄普地尔 乌头碱 哇巴因 氯化钡 氯化钙 肾上腺素 复灌注 心律失常 |
Antiarrhythmia effects of bepridll |
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| GU Shu -Ling,CHEN Jin-Ming,GUI Ja-Yong,PENG Zhen -Yun.Antiarrhythmia effects of bepridll[J].Chinese Pharmacological Bulletin,1992,8(4):285-287. |
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| Authors: | GU Shu -Ling CHEN Jin-Ming GUI Ja-Yong PENG Zhen -Yun |
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| Abstract: | Bepridil (10mg · kg-1) iv elevated the threshold dose of ouabain (15ug · min-1 iv) in guinea-pig and aconitine (10μg · kg-1 · min-1 iv) in rat induced ventricular extrasystole, ventricular tachycardia, ventricular fibrillation and cardiac arrest. It shortened the duration of arrhythmia elicitde by Adr (50ug · Kg-1 iv) in conscious rabbits and by BaCl2 (3mg · kg-1 iv) in rats. It is also effective in preventing reperfusion-induced arrhythmias in aneasthetized rats. |
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| Keywords: | Bepridil A conitine Ouabain Bad_2 CaCl_2 Adrenaline Reperfusion Anhythmia |
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