ESTIMATION OF SERUM Vicfflb LIGHT CHAINS IN RHEUMATOID ARTHRITIS AND CORRELATION WITH CD5-POSITIVE -CELLS |
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| Authors: | SMALLEY HELEN B; TODD JANET; BARNES R M R; THOMPSON R N; ABRAHAM G N; JOHNSON P M |
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| Institution: | *Department of Immunology, University of Liverpool Fazakerley Hospital, Liverpool
 Department of Rheumatology Fazakerley Hospital, Liverpool
 Department of Medicine, University of Rochester Medical Centre Rochester, NY, USA |
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| Abstract: | The presence of Vidllb light chains in the sera of rheumatoidarthritis (RA) patients has been evaluated by an enzyme-linkedimmunosorbent assay (ELISA). V IIIb light chains have been confirmedto be largely restricted to IgM, and were rarely detected inthe IgG fraction of sera. The concentration of total serum VicIIIbdid not significantly vary with age, nor did it correlate withIgM-rheumatoid factor (RF) titre. Although total serumVIIIbwas not significantly increased in RA patients compared withmatched controls, IgM-RFs frequently contained VicIIIb. Usingflow cytometry, CD5-positive B-cells were not increased in theseRA patients compared with healthy laboratory control personnel.Furthermore, there was no direct correlation between total serumIgM VKlllb content and CD5-positive B-cell numbers in peripheralblood KEY WORDS: VkIIIb light chains, Rheumatoid factor (RF), CD5-positive B-cells, Rheumatoid arthritis |
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