Fatty acid composition of plasma and erythrocyte phospholipids in preterm infants |
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| Authors: | S E Shires S P Conway I Rawson P R Dear J Kelleher |
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| Affiliation: | 1. Department of Medicine, St. James''s University Hospital, Leeds, U.K.;2. Department of Paediatrics and Child Health, St. James''s University Hospital, Leeds, U.K.;1. Universidad de Los Andes, Carrera 1 No 18A-70, oficina W803, Bogota, Colombia;2. Banque de France, France;1. ILSI North America Technical Committee on Food and Chemical Safety Summer Fellow, Washington, DC, USA;2. Oak Ridge Institue for Science and Education (ORISE) Fellow at the US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, NC, USA;3. US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, NC, USA;1. LSRO Solutions LLC, 2286 Dunster Lane, Rockville, MD 20854, USA;2. Runke Bioengineering (Fujian) Co., Ltd., Zhao''an County, Zhangzhou City, Fujian Province China;1. LSRO Solutions LLC, 2286 Dunster Lane, Rockville, MD 20854, United States;2. Runke Bioengineering (Fujian) Co., Ltd, Zhao''an County, Zhangzhou City, Fujian Province, China;1. Harvard University, Museum of Comparative Zoology, Cambridge, MA 02138, USA;2. Wright State University, Department of Neuroscience, Cell Biology and Physiology, Dayton, OH 45435, USA;3. University of West Florida, Department of Biology, Pensacola, FL 32514, USA;4. Roanoke College, Department of Biology, Salem, VA 24153, USA;5. University of North Texas, Department of Biological Sciences, Denton, TX 76203, USA |
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| Abstract: | Erythrocyte and plasma phospholipid fatty acids were determined in preterm babies at 0, 6 and 10 weeks. There were highly significant changes in fatty acid composition between birth and 6 weeks in both plasma and erythrocyte phospholipids, the changes being more numerous and quantitatively greater in phosphatidyl choline. There was little further change by 10 weeks. Linoleic acid increased by approximately 100% at 6 weeks in plasma phosphatidyl ethanolamine and 200% in phosphatidyl choline. In erythrocyte phosphatidyl ethanolamine, linoleic acid increased by approximately 150% at 6 weeks and in phosphatidyl choline increased 170%. Arachidonic acid decreased by 54%. The essential fatty acid status of the preterm babies studied using contemporary feeding regimes was satisfactory and by 6 weeks phospholipid fatty acid profiles were comparable with published data for normal healthy breast-fed infants. |
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