围术期输血对患者术后感染的影响

本研究通过对中国人民解放军总医院术后感染病例的回顾性分析，探讨患者围术期的输血状况是否会加重术后感染程度。应用中国人民解放军总医院输血科开发软件“临床输血数据库”进行检索，选取150例外科手术后感染病例，按感染部位分为深部感染组和浅部感染组，对两组患者的年龄、住院时间、红细胞输注量、非红细胞输注量、输血次数和平均每次输血量进行对比分析。结果表明，发生浅部感染患者的中位红细胞输注量和非红细胞输注量分别为4．50（0-59）u和2．95（0-119．6）U，深部感染组中位红细胞输注量和非红细胞输注量分别为9．00（0-153）U和8．05（0-136．6）U，两组患者存在明显差异（P〈0．05）。两组患者最显著的差异是输血次数的不同，发生浅部感染的患者中位输血次数为2（1-31）次，远远低于发生深部感染患者的输血次数4（1-49）次（P〈0．001）。两组患者的平均每次输注量没有明显差异。结论：手术患者围术期的输血量及输血次数同患者术后感染的严重程度似乎呈正相关。

Effects of Perioperative Blood Transfusion on the Severity of Postoperative Infection

This study was purposed to explore whether the blood transfusion of surgical patients can increase the severity of postoperative infection by a retrospective analysis of patients with postoperative infection in Chinese PLA General Hospital. By using a software ＂clinical transfusion database＂ developed by our department, 150 infected surgical cases were retrieved and divided into deep infection group and superficial infection group according to the infected location. These two groups were compared in term of the patient＇s age, duration of hospitalization, red blood cell transfusion volume, none-red cell transfusion volume, transfusion frequency and average transfusion volume. The results showed that red blood cell transfusion volume or none-red cells transfusion volume of patients with superficial infection was 4.50 （0 - 59） U or 2.95 （0 - 119.6） U, and that of deep infection was 9.00 （0 - 153 ） U and 8.05 （0 - 136.6） U, the differences was significant （P 〈 0. 05 ）. Between two groups, the transfusion frequency showed the most significant difference, median in the patients with superficial infection was about 2 （ 1 - 31 ） times, less than the deep infection group about 4 （1 -49） times （P 〈 0.001 ）. There was no significant difference between two groups in the average transfusion volume. It is concluded that perioperative blood transfusion volume and frequency of surgical patients seems to display a positive correlation with the degree of postoperative infection.