| B-Raf基因在非小细胞肺癌中的表达及其临床意义 |
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| 引用本文： | 阎靖芳.B-Raf基因在非小细胞肺癌中的表达及其临床意义[J].医学综述,2013,19(8):1409-1411. |
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| 作者姓名： | 阎靖芳 |
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| 作者单位： | 阎靖芳 (北京军区总医院全军肿瘤内科诊治中心,北京,100700;山西医科大学第二临床医学院,太原,030001)； |
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| 摘 要： | 非小细胞肺癌(NSCLC)是肺癌的一种,它具有极高的病死率。在NSCLC的发生、发展中丝裂原活化蛋白激酶(MAPK)通路异常激活起重要作用,而B-Raf基因是MAPK通路中MEK/ERK最为关键的激活因子,进而对肿瘤细胞的增殖、分化和凋亡等方面起作用。B-Raf基因表达异常存在于NSCLC中并影响它的发生及预后,针对B-Raf基因的靶向治疗是一个新的研究热点。
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| 关 键 词： | 非小细胞肺癌 B-Raf基因 分子靶向治疗 |
The Expression of B-Raf in Non-small Cell Lung Cancer and Its Clinical Significance |
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| YAN Jing-fang,YU Zhong-he.The Expression of B-Raf in Non-small Cell Lung Cancer and Its Clinical Significance[J].Medical Recapitulate,2013,19(8):1409-1411. |
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| Authors: | YAN Jing-fang YU Zhong-he |
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| Institution: | 1.(1.Center of Diagnosis and Treatment of Oncology,Military General Hospital of Beijing PLA,Beijing 100700,China;2.The Second Clinical School of Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Non-small cell lung cancer(NSCLC) is one kind of lung cancer,with high death rate.Abnormal activation of mitogen-activated protein kinase(MAPK) pathway plays a crucial role in the pathogenesis of NSCLC,of which B-Raf genes is the most critical activating factor of MAPK pathway MEK/EPK,playing roles in tumor cell proliferation,differentiation,apoptosis,and so on.Abnormal B-Raf expression have been found in NSCLC which affects its development and prognosis.Targeted therapy for B-Raf gene is a new research focus. |
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| Keywords: | Non-small cell lung cancer B-Raf gene Molecular targeted therapy |
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