脑白质疏松症的研究进展

脑白质疏松症(LA)是一种常见的神经影像学征像,与脑缺血损伤有关,属于脑小血管病变的一个类型。临床上可导致认知功能和下肢运动功能障碍,严重影响患者的日常生活。近年来,随着CT及磁共振成像等影像学检查技术的进步和普及,LA的检出率大大增加。LA受到越来越多的关注。LA的发病机制是多方面的,但具体机制仍不完全清楚。该文就LA的影像特点、病理学改变、临床表现、发病机制及近年来研究热点予以综述。

Research Progress of Leukoaraiosis

Leukoaraiosis(LA) is a common neuroimaging finding associated with cerebral ischemia belonging to one type of SVD.LA has manifestations of cognitive impairment and decreased mobility of lower limbs in clinic,which impacts the patients′quality of life seriously.With the availability of improved brain imaging techniques such as CT and MRI,the diagnosis rate of LA have greatlyincreased in recent years,and has drawn more attention from scholars.The pathogenesis of LA is probably multifactorial and the specific mechanism is still not completely clear.Here is to summarize the research on imaging features,pathological changes,clinical manifestations,pathogenesis and hot points of LA in recent years.