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Glycophorin A inhibits lysis by the complement attack phase |
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| Authors: | H Brauch D Roelcke U Rother |
| Affiliation: | Institute of Immunology and Serology, University of Heidelberg, Federal Republic of Germany |
| Abstract: | A glycoprotein from human erythrocyte membranes has been found to inhibit lysis of target cells by the attack-phase components C5-C9 from human complement. The inhibiting molecule was purified and identified as glycophorin A. Thus, glycophorin A may have a regulatory function in the lytic complement attack on isologous cells. |
| Keywords: | complement ethylenediaminetetraacetic acid veronal-buffered saline erythrocyte phenylmethylsulfonylfluoride ε-aminocaproic acid benzamidine complement components optical density sodium dodecyl sulfate polyacrylamide gel electrophoresis periodic acid/Schiff neuraminic acid |
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