Serum Alkaline Phosphatase of Large Molecular Weight |
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| Authors: | HATTORI, NOBU MAISHI, SHOKO |
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| Affiliation: | Department of Internal Medicine, National Cancer Center Hospital and Endocrinology Division, National Cancer Center Research Institute, National Cancer Center Tokyo, Japan |
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| Abstract: | Bio-Gel A-5m and Bio-Gel A-150m gel-chromatography of serumalkaline phosphatase was carried out. Large molecular alkalinephosphatase in serum which exhibited alkaline phosphatase activityprior to any treatment was obtained and assumed tobe cell debrisenzyme. By the treatment with Triton X-100, its molecular weightbecame smaller and alkaline phosphatase activity increased.Treatment with DOC also lowered the molecular size, but alkalinephosphatase activity was inhibited. Electron microscopic studyof ultracentrifugation sediment of this material revealed celldebris like features possessing alkaline phosphatase activitythemolecular weight of this meterial may be over ten million witha very broad size distribution. |
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