28个家庭HBV感染集聚者血清学动态观察及10年随访

报告２８个家庭ＨＢＶ感染１６４人的血清学动态观察及１０年随访。１０年中曾有８２人患过急性肝炎，９例死于原发性肝癌，８例死于肝硬化，７例死于重型肝炎，１４例慢活肝，８例慢迁肝。结果表明，ＨＢＶ感染家庭集聚者肝癌、肝硬化、重型肝炎的发生率和病死率极高。本文提示了在乙肝的防治工作中切实加强阻断母婴之间传播的同时，应积极开展对ＨＢＶ感染家庭集聚人群的随访研究．

A Dynamic Serology Observation on Members of 28 Homes with HBV Aggregative Infection and 10 Years Follow-up Study

homes with HBV aggregative infecion were investigated. A dynamic serology observation was carried out in 164 members of homed. In period of 10 years follow-up,among the 164 cases,82 were infected with acute hepatitis.9 died from primary hepatoma,8 from post hepatitic cirrhosis,7 from severe hepatitis,14 developed to chromic active hepatitis,8 to chronic persistent hepatitis.The results showed tha the incidences of hepatoma,cirrhosis and severe hepatitis were very high in the member of the home with HBV aggregative infection.The incidence of chronic active hepatitis in these membets was higher than that sporadic population with HBV infection(P<0.01).Therefore,during strengthening blocking the transmission of hepatitis B between mother and baby,meantime would develop the follow-up study on the member of home with HBV aggregative infection.