| 三氧化二砷对H22肝癌荷瘤小鼠免疫功能及瘤体的影响 |
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| 引用本文： | 唐印华,刘铁夫,庄丽维,田永刚,梁 桃,马占军.三氧化二砷对H22肝癌荷瘤小鼠免疫功能及瘤体的影响[J].中国肿瘤生物治疗杂志,2002,9(3):172-174. |
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| 作者姓名： | 唐印华 刘铁夫 庄丽维 田永刚 梁 桃 马占军 |
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| 作者单位： | 1. 哈尔滨医科大学第一临床医学院消化内科,哈尔滨,150001
2. 哈尔滨市血液肿瘤研究所,肿瘤外科 |
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| 摘 要： | 目的 探讨三氧化二砷(As2O3)对H22肝癌荷瘤小鼠免疫功能的影响及实体瘤生长情况.方法 利用流式细胞仪及改进的MTT还原法分别对正常小鼠、荷瘤小鼠对照组、荷瘤小鼠As2O3治疗组进行T细胞亚群及NK细胞活性(NKCA)的测定,并比较各组瘤重,计算瘤重抑制率.结果 肝癌小鼠荷瘤对照组与正常组比较,CD3+,CD4+,CD4+/CD8+及NKCA均明显减少(P<0.01);低剂量及高剂量 As2O3治疗组与荷瘤对照组比较,CD3+, CD4+, CD4+/CD8+及NKCA均明显升高(P<0.05),CD8+无明显变化;而高剂量 As2O3治疗组与低剂量 As2O3治疗组比较,CD4+,NKCA明显升高(P<0.05),CD3+, CD4+/CD8+无明显变化.治疗组瘤重抑制率分别为39.12%,45.74%,病理观察可见间质内大量炎症细胞浸润.结论 AS2O3 能抑制实体肿瘤的生长,提高肝癌小鼠的免疫功能,这是一值得继续研究的临床课题.
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| 关 键 词： | 免疫功能 三氧化二砷 肝癌 T细胞亚群 NK细胞活性 |
| 文章编号： | 1007-385X(2002)03-0172-03 |
| 收稿时间： | 4/2/2002 12:00:00 AM |
| 修稿时间： | 4/2/2002 12:00:00 AM |
The Immune Effects and Solid Tumor Growth of Arsenic Trioxide on Experimental H22 Hepatoma-Bearing Mice |
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| TANG Yin-hu,LIU Tie-fu,ZHUANG Li-wei,TIAN Yong-gang,LIANG Tao,and MA Zhan-jun.The Immune Effects and Solid Tumor Growth of Arsenic Trioxide on Experimental H22 Hepatoma-Bearing Mice[J].Chinese Journal of Cancer Biotherapy,2002,9(3):172-174. |
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| Authors: | TANG Yin-hu LIU Tie-fu ZHUANG Li-wei TIAN Yong-gang LIANG Tao and MA Zhan-jun |
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| Institution: | Department of Digestive, First Affiliated Hospital, Haerbin Medical University, Haerbin, 150001, China;Department of Digestive, First Affiliated Hospital, Haerbin Medical University, Haerbin, 150001, China;Department of Digestive, First Affiliated Hospital, Haerbin Medical University, Haerbin, 150001, China;Department of Digestive, First Affiliated Hospital, Haerbin Medical University, Haerbin, 150001, China;Department of Digestive, First Affiliated Hospital, Haerbin Medical University, Haerbin, 150001, China;Department of Digestive, First Affiliated Hospital, Haerbin Medical University, Haerbin, 150001, China |
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| Abstract: | |
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| Keywords: | tumor bearing mice arsenic trioxide liver cancer T lymphocyte subsets NK cells activity |
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