The discriminative stimulus effect of MK-801 in ketamine-trained rats |
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Authors: | M J Benvenga A V Wing R A Del Vecchio |
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Affiliation: | Department of Pharmacology, Anaquest/BOC Health Care, Murray Hill, NJ 07974. |
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Abstract: | MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate] was assessed for its discriminative stimulus properties in rats trained to discriminate ketamine (7 mg/kg) from vehicle. MK-801 generalized to ketamine in a dose dependent manner with a maximum effect at 0.2 mg/kg, while ketamine generalized fully at 10 mg/kg. These results indicate that ketamine and MK-801 may share a common mechanism of action, which is related to the phencyclidine recognition site in the brain. |
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