秋水仙碱对急性脑梗死预后的影响

目的　探讨秋水仙碱对急性脑梗死患者预后的影响。方法　将60例急性脑梗死患者随机分为两组。对照组30例,接受急性脑梗死的基本治疗;治疗组30例,接受秋水仙碱1.5 mg/d和基本治疗,共14 d。两组分别于入院后和发病后1个月测量血白细胞计数、纤维蛋白原和血沉; 同时测量脑梗死灶体积变化、神经功能评分(MESS)及日常生活活动(ADL)量表记分的变化, 并将两组进行比较。结果　(1)秋水仙碱治疗后脑梗死体积较治疗前明显缩小(P<0.01); (2)血清纤维蛋白原水平、白细胞计数及血沉治疗后下降较对照组差异有显著意义(P<0.01); (3)神经功能缺损评分显著低于对照组(P<0.001); 而日常生活活动量表评分显著高于对照组(P<0 .001)。结论　秋水仙碱能缩小脑梗死体积、减轻神经功能缺损, 改善急性脑梗死患者的预后。

Influence of colchicine on the prognosis of the acute cerebral infarction

Objective To investigate the influence of colchicine(Col) on the prognosis of the acute cerebral infarction(ACI).Methods 60 patients of ACI were divided into control group(30 patients) and treatment group(30 patients).The control group was given general therapy.The Col 1.5mg/d were given to the treatment group for 14 days besides the general therapy.The serum level of fibrinogen,ESR and WBC count was detemined before and after treatment 4th week in all patients.The cerebral infarct volume were measured.The neurofunctional deficite were evaluated with MESS,the acticity of daily living(ADL) was evaluated with brathel index(BI) at admission and after treatment 4th week in all patients,and compared the treatment group with the control group.Results (1)Compared with the before treatment,cerebral infarct volume after the treatment with Col was decrease(P<0.05);(2)The decrease in the serum level of fibringen.ESR and WBC count in the treatment group was more obvious than that in the control group(P<0.01);(3)Compared with those of the control group,the decrease in neurofunctional deficit scores in the treatment group was more obvious(P<0.001),the scores of BI were significantly increased(P<0.001).Conclusion Col can decrease cerebral infarct volume,and can not only reduce the neurofunctional deficite,but also improve the prognosis of the ACI patients.