| 下丘脑室旁核参与诱发癫痫对细胞免疫功能的抑制作用 |
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| 引用本文： | 张玉芹,聂辉,王阿敬,邹飞. 下丘脑室旁核参与诱发癫痫对细胞免疫功能的抑制作用[J]. 中国现代医学杂志, 2003, 13(10): 35-36,39 |
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| 作者姓名： | 张玉芹 聂辉 王阿敬 邹飞 |
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| 作者单位： | 1. 武汉科技大学医学院,430080
2. 华中科技大学同济医学院,武汉,430030 |
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| 基金项目： | 湖北省教育厅科研基金资助 (NO2 0 0 1A190 0 9) |
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| 摘 要： | 目的：探讨下丘脑室旁核在致痫大鼠对细胞免疫功能的影响及机制。方法：大鼠大脑皮层应用化学致痫荆马桑内酯引起痫样放电，以刀豆素A刺激脾淋巴细胞增殖反应为指标，观察电损毁和电刺激下丘脑室旁核对致痫动物细胞免疫功能的影响。结果：马桑内酯诱发动物脑细胞异常放电时，可抑制刀豆素A刺激脾淋巴细胞增殖反应，电损毁双侧下丘脑室旁核可减弱这种抑制效应，电刺激室旁核可增强这种抑制效应。结论：下丘脑室旁核参与了诱发脑细胞异常放电时对细胞免疫功能的抑制作用。
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| 关 键 词： | 下丘脑室旁核癫痫 细胞免疫功能 |
INVOLVEMENT OF PARAVENTRICULAR NUCLEUS IN THE EPILEPSY-INDUCED INHIBITION OF CELLULAR IMMUNE FUNCTION IN RATS |
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| Zhang Yuqin,Nie Hui. Medical College Wuhan University of Science and Technology,Wuhan Wang Ajing,Zhou Fei Tongji Medical College,Huazhong University of Science and Technology,Wuhan. INVOLVEMENT OF PARAVENTRICULAR NUCLEUS IN THE EPILEPSY-INDUCED INHIBITION OF CELLULAR IMMUNE FUNCTION IN RATS[J]. China Journal of Modern Medicine, 2003, 13(10): 35-36,39 |
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| Authors: | Zhang Yuqin Nie Hui. Medical College Wuhan University of Science Technology Wuhan Wang Ajing Zhou Fei Tongji Medical College Huazhong University of Science Technology Wuhan |
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| Affiliation: | Zhang Yuqin,Nie Hui. Medical College Wuhan University of Science and Technology,Wuhan 430080 Wang Ajing,Zhou Fei Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective:To explore the influence of hypothalamic paraventricular nucleus (PVN) on cellular immune function and its mechanism in the epileptic animal model.Methods:In the experiments, application of chemical convulsive agent coriaria lactone(CL) to cerebral cortex caused the epileptiform discharges in rats. The proliferation of Con A-stimulated splenic lymphocytes were observed after the hypothalamic PVN were cauterized and stimulated.Results:The proliferation of Con A-stimulated splenic lymphocytes was inhibited and this inhibitory effect could be decreased by electrolytical lesion of bilateral hypothalamic PYN , but enhanced by electrical stimulation of PVN in the epileptic rats.Conclusion:The above experimental results suggest that hypothalamic PVN participated in the inhibition of cellular immune function in the epileptic rats. |
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| Keywords: | Hypothalamic Paraventricular Nucleus Epilepsy Cellular Immune Function |
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