| 降钙素基因相关肽在哮喘豚鼠内脏传入系统的定量分析 |
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| 引用本文： | 方秀斌,刘晓湘,佟晓杰,王振宇. 降钙素基因相关肽在哮喘豚鼠内脏传入系统的定量分析[J]. 神经解剖学杂志, 2000, 16(2): 157-159 |
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| 作者姓名： | 方秀斌 刘晓湘 佟晓杰 王振宇 |
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| 作者单位： | 中国医科大学,脑研究所,沈阳,110001 |
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| 基金项目： | 国家自然科学基金资助项目(No.39670335) |
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| 摘 要： | 本文应用放射免疫分析方法研究了实验性哮喘豚鼠与下呼吸道有关的内脏传入系统内降钙素基因相关肽含量的变化 ,藉以探讨降钙素基因相关肽在哮喘发病时的作用机制。结果表明 ,哮喘豚鼠与下呼吸道有关的内脏传入系统 (结状神经节、C7～T5 节段脊神经节和脊髓后角、孤束核等处 )中的降钙素基因相关肽含量明显高于各对照组 ( P<0 .0 5)。本研究提示 ,下呼吸道和肺的内脏传入成分中的降钙素基因相关肽可能参与哮喘发病的病理生理过程。
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| 关 键 词： | 降钙素基因相关肽 结状神经节 脊神经节 脊髓后角 孤束核 哮喘 豚鼠 |
| 修稿时间： | 1999-07-08 |
QUANTITATIVE ANALYSIS OF CALCITONIN GENE RELATED PEPTIDE LEVELS IN THE VISCERAL AFFERENT SYSTEM OF THE ASTHMATIC GUINEA PIG |
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| Fang Xiubin,Liu Xiaoxiang,Tong Xiaojie,Wang Zhenyu. QUANTITATIVE ANALYSIS OF CALCITONIN GENE RELATED PEPTIDE LEVELS IN THE VISCERAL AFFERENT SYSTEM OF THE ASTHMATIC GUINEA PIG[J]. Chinese Journal of Neuroanatomy, 2000, 16(2): 157-159 |
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| Authors: | Fang Xiubin Liu Xiaoxiang Tong Xiaojie Wang Zhenyu |
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| Abstract: | The calcitonin gene related peptide (CGRP) levels in the visceral afferent system of asthmatic guinea pigs were measured by means of radioimmunoassay. The results showed that CGRP levels in the primary afferent system (nodose ganglia, C 7～T 5 spinal ganglia, dorsal horn of C 7～T 5 spinal cord and solitary nucleus) were much higher than those in the normal control group(P<0.05). These data indicated that CGRP in the primary afferent system might be involved in the pathogenesis of asthma. |
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| Keywords: | calcitonin gene related peptide nodose ganglion spinal ganglion dorsal horn solitary nucleus asthma guinea pig |
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