| 水杉总黄酮抗实验性心肌肥厚及抑制心室c-Fos蛋白表达的作用 |
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| 引用本文： | 刘维莞,杨晓茹,屠治本,石明健,糜留西,王红英,敖英.水杉总黄酮抗实验性心肌肥厚及抑制心室c-Fos蛋白表达的作用[J].中草药,2001,32(4):329-332. |
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| 作者姓名： | 刘维莞 杨晓茹 屠治本 石明健 糜留西 王红英 敖英 |
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| 作者单位： | 1. 武汉大学医学院 药理学教研室，湖北 武汉 430071
2. 中国科学院武汉植物研究所，湖北 武汉 430074 |
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| 基金项目： | 国家自然科学基金资助课题（NO.39970085） |
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| 摘 要： | 目的：观察水杉总黄酮（TFM）对容量超负荷大鼠心肌肥厚的作用及其对心室c-Fos蛋白表达的影响。／方法：采用腹腔动－静脉造瘘建立大鼠容量超负荷模型，ig给予TFM，免疫组化测定心室c-Fos蛋白的相对含量，结果：TEM剂量依赖性地减轻大鼠心脏重量，抑制心室RNA和蛋白质合成，并抑制心室c-Fos蛋白表达，结论：TFM可预防容量超负荷大鼠心肌肥厚的形成，抑制心室c-Fos蛋白表达可能是其分子机制之一。
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| 关 键 词： | 水杉总黄酮 容量超负荷 心肌肥厚 c－Fos蛋白 大鼠 |
| 文章编号： | 0253-2670(2001)04-0329-04 |
| 收稿时间： | 2000/6/18 0:00:00 |
| 修稿时间： | 2000年6月18日 |
Inhibitory effects of total flavones of Metasequoia glyptostroboides on experimental cardiac hypertrophy and expression of c-Fos protein in ventricle |
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| LIU Weiwan,YANG Xiaoru,TU Zhiben,SHI Mingjian,MI Liuxi,WANG Hongying and AO Ying.Inhibitory effects of total flavones of Metasequoia glyptostroboides on experimental cardiac hypertrophy and expression of c-Fos protein in ventricle[J].Chinese Traditional and Herbal Drugs,2001,32(4):329-332. |
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| Authors: | LIU Weiwan YANG Xiaoru TU Zhiben SHI Mingjian MI Liuxi WANG Hongying and AO Ying |
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| Institution: | LIU Wei wan 1,YANG Xiao ru 1,TU Zhi ben 2,SHI Ming jian,MI Liu xi 2,WANG Hong ying 1,AO Ying 1 |
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| Abstract: | Object To observe the effects of total flavones of Metasequoia glyptostroboides Hu et Cheng (TFM) on volume overload cardiac hypertrophy and the expression of c Fos protein in rat Methods Volume overload cardiac hypertrophy of rat was induced by aortocaval shunts The rats were given ig TFM (400, 40 and 4 mg/kg/d) c Fos protein in the ventricles were measured by immunocytochemical study Results TFM at the above dosage decreased heart weight and contents of RNA and protein in the myocardium, inhibited the expression of c Fos protein in the ventricles Conclusion TFM can prevent volume overload cardiac hypertrophy in rats The inhibitory effects on the expression of c Fos protein may be its mechanism in the molecular level |
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| Keywords: | total flavones of Metasequoia glyptostroboides Hu et Cheng (TFM) volume overload cardiac hypertrophy c Fos |
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