Effects of antioxidants on aflatoxin-induced hepatic tumors in rats |
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| Authors: | F Iverson J Campbell D Clayson S Hierlihy E Labossiere S Hayward |
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| Institution: | 1. Department of Animal Sciences, University of Wisconsin - Madison, WI 53706, United States;2. Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53706, United States;3. School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, SP 18618-681, Brazil;4. School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal 14884-900, Brazil;5. Animal Sciences Department, Federal University of Lavras, MG 37200-00, Brazil;6. Federal University of Triângulo Mineiro, Iturama, MG 38280-000, Brazil;1. Dairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, 2000 College Street, Sherbrooke, QC, Canada;2. Swine and Poultry Infectious Diseases Research Center (CRIPA), Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada;3. Groupe de recherche sur les maladies infectieuses du porc (GREMIP), Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada;4. Département des sciences animales, Faculté des sciences de l''agriculture et de l''alimentation, Université Laval, Québec, Canada;5. Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada |
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| Abstract: | Female Wistar rats pretreated with Aflatoxin B1 (AFB) were administered reduced glutathione, butylated hydroxytoluene, methionine or ascorbic acid on a daily basis, p.o., for 8 months. None of the treatments produced a decrease in incidence or size of hepatic nodules. While there was some evidence that ascorbic acid reduced the incidence of cystic cholangioma, the ascorbic acid and methionine treatment groups also contained significantly fewer animals surviving to the 26-month sacrifice. The lack of effect of glutathione is not consistent with previous work showing a marked glutathione dependent regression of AFB-induced hepatocellular carcinoma. |
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