The human leucocyte P30 antigen: properties and assessment of value as a clonal marker |
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| Authors: | H. Zola H. A. Moore I. K. Hunter A. Hohmann P. J. Mcnamara J. Bradley P. Mum A. Morley J. V. Melo D. Catovsky |
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| Affiliation: | Departments of Clinical Immunology;Haematology, Flinders Medical Centre, Bedford Park, South Australia;MRC Leukaemia Unit, Royal Post-Graduate Medical School, London, U.K. |
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| Abstract: | FMC3 and FMC29 are monoclonal antibodies which react with a 30,000 Dalton molecule expressed on the lymphocyte surface membrane. The molecule is a protein which does not appear to be N-glycosylated. The antigen, which is also expressed intracellularly, does not appear to be a marker of differentiation or maturation. Polyclonal cell populations, such as peripheral blood lymphocytes, show a bimodal distribution of surface antigen density, whilst monoclonal cell populations analysed quantitatively showed unimodal antigen density distributions. This suggests the antigen may be a clonal marker. |
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