小儿智力糖浆联合盐酸哌甲酯片治疗儿童注意缺陷多动障碍的疗效观察

目的探讨小儿智力糖浆联合盐酸哌甲酯片治疗儿童注意缺陷多动障碍的临床疗效。方法选择2012年1月—2014年12月重庆市开县人民医院儿科收治儿童注意缺陷多动障碍患者90例,随机分为对照组和治疗组,每组45例。对照组患者口服盐酸哌甲酯片,2片/次,1次/d。治疗组患者在对照组的治疗基础上口服小儿智力糖浆,10 m L/次,2次/d。3周为1个疗程,全部患者均治疗3个疗程。观察两组的临床疗效,同时比较两组治疗前后Conner行为评定量表各因子评分及不良反应情况。结果治疗后,对照组和治疗组总有效率分别为77.78%、88.89%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者冲动多动、多动指数、学习问题、品行问题、焦虑、身心问题评分均较较治疗前显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组治疗后各评分均显著低于对照组,两组比较差异有统计学意义(P0.05)。两组不良反应发生率比较差异无统计学意义。结论小儿智力糖浆联合盐酸哌甲酯片治疗儿童注意缺陷多动障碍,能够显著提高临床疗效,且无严重不良反应,具有一定的临床推广价值。

Clinical observation of Xiaoer Zhili Syrup combined with Methylphenidate Hydrochloride Tablets in treatment of attention deficit hyperactivity disorder

Objective To investigate the clinical effect of Xiaoer Zhili Syrup combined with Methylphenidate Hydrochloride Tablets in treatment of attention deficit hyperactivity disorder. Methods Patients (90 cases) with attention deficit hyperactivity disorder in the derpartment of paediatrics of People's Hospital of Kaixian County in Chongqing from January 2012 to December 2014 were randomly divided into control and treatment groups. Each group had 45 cases. Patients in control group were po administered with Methylphenidate Hydrochloride Tablets, 2 tablets/time, once daily. Patients in treatment group were po administered with Xiaoer Zhili Syrup on the basis of the control group, 10 mL/time, twice daily. A course of treatment included 3 weeks, and the patients in two groups maintained the treatment for three coures. After treatment, the efficacy was evaluated, and the changes of each factor score in Conner behavior rating scale and adverse reactions in two groups before and after treatment were compared. Results The efficacies in the control and treatment groups were 77.78% and 88.89%, respectively, and there were differences between two groups (P < 0.05). After treatment, scores of impulse hyperactivity, index of hyperactivity, learning problems, character, anxiety, physical and mental problems in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in the treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xiaoer Zhili Syrup combined with Methylphenidate Hydrochloride Tablets can significantly improve the clinical curative effect in treatment of attention deficit hyperactivity disorder with no serious adverse reaction, which has a certain clinical value.