辛伐他汀对糖尿病大鼠肾组织中核因子-κB活性和ICAM-1表达的影响

目的:探讨辛伐他汀对实验性2型糖尿病大鼠肾组织中核因子NF-κB及炎性细胞因子细胞间粘附分子-1(ICAM-1)的影响及其机制。方法:将36只大鼠随机分为对照组,糖尿病组和糖尿病辛伐他汀处理组,后两组以高糖高脂饮食加小剂量链脲佐菌素(STZ)制备实验性2型糖尿病大鼠模型。采用免疫组织化学染色法检测各组大鼠肾组织中NF-κB、ICAM-1的表达水平并作比较。结果:糖尿病组大鼠肾组织中NF-κB、ICAM-1的表达较对照组明显增加。以辛伐他汀处理4周后,NF-κB、ICAM-1活性降低(P<0.05),肾功能各指标及肾组织病理学损害改善。结论:实验性2型糖尿病大鼠肾组织中NF-κB活性增加,炎性细胞因子ICAM-1表达上调。辛伐他汀的肾保护作用至少部分是与其不依赖调血脂作用的,减少肾组织中NF-κB的活性和ICAM-1的表达有关。

Inhibitory effects of simvastatin on activation of renal nuclear factor-kappa B and expression of intercellular adhesion molecule-1 in experimental type 2 diabetic rat

Objective To investigate the effects of simvastatin on activation of renal nuclear factor-kappa B (NF-κB) and expression of intercellular adhesion molecule-1(ICAM-1) in type 2 diabetic rats.Methods Thirty-six rats were randomly divided into control group,diabetic group and simvastatin treatment group.The rats of the latter two groups were intraperitoneally injected low-dose streptozotocin(STZ,30mg/kg) after having the sucrose and fat enriched diets (20%sucrose,10%pig fat,2.5%cholesterol ) for four weeks.Imm...