| 维生素D受体基因多态性对慢性血液透析患者骨代谢的影响 |
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| 引用本文： | 孙珉丹,王国印,杜玉君. 维生素D受体基因多态性对慢性血液透析患者骨代谢的影响[J]. 中华内科杂志, 2000, 39(6): 384-387 |
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| 作者姓名： | 孙珉丹 王国印 杜玉君 |
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| 作者单位： | 白求恩医科大学第一临床学院肾内科 |
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| 摘 要： | 探讨慢性血液透析患者维生素Ｄ受体基因多态性对骨代谢的影响。方法用ＤＥＸＡ法测定了２０１例维持性血液透析患者的骨密度，用ＲＦＬＰｓ解析法分析ＶＤＲ的基因多态性，同时考察两者间的关系。
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| 关 键 词： | 血液透析 基因多态性 骨代谢 维生素D受体 |
| 修稿时间： | 1999-08-29 |
Effect of vitamin D receptor gene on bone mineral density in chronic hemodialysis patients |
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| SUN Mindan,WANG Guoyin,DU Yujun. Effect of vitamin D receptor gene on bone mineral density in chronic hemodialysis patients[J]. Chinese journal of internal medicine, 2000, 39(6): 384-387 |
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| Authors: | SUN Mindan WANG Guoyin DU Yujun |
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| Affiliation: | SUN Mindan,WANG Guoyin,DU Yujun Department of Nephrology,Bethune Medical Uniuersity,Changchun 130021,China |
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| Abstract: | Objective To study the gene diversity of vitamin D receptor(VDR) in chronic hemodialysis patients and its effect on bone mineral supersession. Methods In two hundred and one chronic hemodialysis patients bone mineral density was studied with DEXA method and the gene diversity of VDR with RFLP analysis.Their relation was also observed. Results Chronic hemodialysis patients with VDR gene type of Bb had higher numerical value of HS PTH but lower numerical value of bone mineral density of lumbar vertebrae and radius as compared with other types of gene diversity. Conclusion Bone metabolism in chronic hemodialysis patients is affected by inheritance factors such as clinical gene types of VDR and may predict the occurrence of osteoporosis and other bone mineral diseases of kidney origin as well as to provide guidelines for treatment. |
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| Keywords: | Gene Bone diseases metabolic Hemodialysis |
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