藏药七十味珍珠丸对阿尔茨海默病患者认知功能及氧化应激的影响

目的 探讨藏药七十味珍珠丸(RNSP)对阿尔茨海默病(AD)AD的作用机制.方法 筛选出AD患者48例,随机分为治疗组及对照组,治疗4、12 w后分别进行认知功能评价及血浆超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)及一氧化氮合酶(NOS)的测定.结果 AD 患者经RNSP治疗后,与对照组比较,简易精神状态量表(MMSE)总分、认知分量表(ADAS-cog)和日常生活活动量表(ADL)均有明显改善(P＜0.01,P＜0.05),治疗组SOD升高(P＜0.05), NOS水平显著降低(P＜0.01).结论 RNSP具有明显改善AD患者认知功能,提高血浆SOD含量,降低NOS水平,改善脑功能的作用.

Effect of Ratnasampil on Alzheimer's disease patient's cognitive function and oxidative stress

Objective To observe the effect of Ratnasampil (RNSP) on Alzheimer's disease (AD) patient's cognitive function and oxidative stress and explore its mechanism. Methods 48 AD patients were selected and divided into treatment group (treated with RNSP) and control group (treated with Piracetam). After 4 and 12 weeks, patient's cognitive function, superoxide dismutase (SOD), malonaldehyde (MDA), nitrogen monoxide (NO) and nitric oxide synthase (NOS) were detected.Results Compared with control group, the patients' MMSE, ADAS-cog and ADL score were all improved (P＜0.01, P＜0. 05), the level of SOD were increased (P＜0.05) and the level of NOS were decreased (P＜0.01) in RNSP group. Conclusions RNSP has the effect of improving the cognitive function, increasing the level of SOD, decreasing the level of NOS, and improving the function of brain.