冷冻治疗对尖锐湿疣病人T淋巴细胞亚群及白细胞介素-2水平的影响

①目的　探讨冷冻治疗对尖锐湿疣 (CA)病人免疫功能的影响。②方法　采用间接免疫荧光法和ELISA法分别对 3 6例CA病人冷冻治疗前后不同时期及 15例正常人外周血T淋巴细胞亚群、血清白细胞介素 2(IL 2 )水平进行测定。③结果　与正常组比较 ,CA病人治疗前外周血中CD4+细胞百分率降低 (F =2 3 8.5 70 ,q =17.495 ,P <0 .0 5 ) ,CD4+/CD8+比值降低 (F =2 0 6.3 43 ,q =18.0 60 ,P <0 .0 1) ,CD8+细胞百分率升高 (F =3 43 .45 9,q =3 0 .3 5 9,P <0 .0 1) ,血清IL 2水平降低 (F =95 .3 3 7,q =13 .841,P <0 .0 5 ) ;冷冻治疗后以上指标与对照组比较 ,均有明显改善 (F =95 .3 3 7～ 3 43 .45 9,q =17.5 18～ 2 9.95 6,P <0 .0 1)。 ④结论　冷冻治疗可以提高CA病人的免疫功能

THE EFFECT OF CRYO-TREATMENT ON T-LYMPHOCYTE SUBPOPULATION AND SERUM INTERLEUKIN-2 IN PATIENTS WITH CONDYLOMATA ACUMINATA

Objective To investigate the effects of cryo-treatment on the status of immunological function in patients with condylomata acuminata ( CA). Methods T-lymphocyte subpopulation of peripheral blood was detected by indirect immunofloresence and the level of serium IL-2 was measured with ELISA in 36 patients with CA and 15 normal controls. Results Comparing with the normal controls , the parameters of the patients before the treatment showed that CD4 + cell percentage decreased (F=238.570,q=17.495,P<0.05) and CD4 + / CD8 + ratio decreased as well (F=206.343,q=18.060,P<0.01), and CD8 + cell percentage increased (F=343.459,q=30.359,P<0.01), and the serum IL-2 level lowered (F=95.337,q=13.841, P< 0.05). After the treatment , the above parameters improved markedly as compared with the controls (F=95.337-343.459, q= 17.518-29.956,P<0.01). Conclusion Cryotreatment can improve the immunological function of patients with CA.