PENICILLINASE-PRODUCING NEISSERIA GONORRHOEA AS A CAUSE OF NEONATAL AND ADULT OPHTHALMIA |
| |
| Authors: | PATRICK LOCKIE FRACO FRACS LAU KWOK LEONG BSc DAPE ANN LOUIS BSc |
| |
| Affiliation: | Department of Ophthalmology, Hospital Universiti, Universiti Sains Malaysia;Department of Microbiology, Hospital Universiti, Universiti Sains Malaysia;Department of Microbiology, Kota Bharu General Hospital, Malaysia |
| |
| Abstract: | A retrospective analysis of 80 cases of gonococcal ophthalmia revealed six (7.5%) to be due to penicillinase-producing Neisseria gonorrhoeae (PPNG), five neonatal cases and one adult. All six cases were finally cured, but best results were obtained with topical chloramphenicol and single-dose spectinomycin (40 mg/kg) given intramuscularly. All gonococcal isolates should be tested promptly for penicillinase production, and if this is present systemic treatment, modified to spectinomycin or penicillinase-stable cephalosporin, should be given as single-dose treatment. |
| |
| Keywords: | Neonatal ophthalmia penicillinase-producing Neisseria gonorrhoeae spectinomycin. |
|
|
