| 蛋白质Z、蛋白质Z依赖性蛋白酶抑制物与卒中 |
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| 引用本文： | 陈奕农,储照虎.蛋白质Z、蛋白质Z依赖性蛋白酶抑制物与卒中[J].国际脑血管病杂志,2009,17(3). |
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| 作者姓名： | 陈奕农 储照虎 |
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| 作者单位： | 皖南医学院弋矶山医院神经内科,芜湖,241000 |
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| 摘 要： | 蛋白质Z(proteinz,PZ)是一种维生素K依赖性蛋白,作为蛋白质Z依赖性蛋白酶抑制物(protein Z-dependent protease inhibitor,ZPI)的辅助因子,在磷脂和钙离子存在的条件下,能抑制凝血因子Ⅹa,使ZPI活性提高近1 000倍,从而在m栓形成过程中发挥作用.ZPI可单独抑制凝血因子Ⅺa.ZPI的活性也在抑制凝血因子Ⅹa和Ⅺa的过程中被消耗.文章对Pz、ZPI的生物特性及与卒中的关联做了综述.
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| 关 键 词： | 蛋白质Z 蛋白质Z依赖性蛋白酶抑制剂 卒中 |
Protein Z, protein Z-dependent protease inhibitor and stroke |
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| CHEN Yi-nong,CHU Zhao-Hu.Protein Z, protein Z-dependent protease inhibitor and stroke[J].International Journal of Cerebrovascular Diseases,2009,17(3). |
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| Authors: | CHEN Yi-nong CHU Zhao-Hu |
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| Abstract: | Protein Z (PZ) is a vitamin K-dependent protein. As a cofactor for the protein Z-dependent protease inhibitor (ZPI), it inhibits coagulation factor X under the existence of phospholipid and calcium ion, and increases the ZPI activity by nearly 1000-fold, thus it plays a role in the process of thrombosis. ZPI inhibits coagulation factor Ⅺ a alone. ZPI activity is also consumed in the process of inhabiting factor Ⅹa and Ⅺa. This article reviews the biological characteristics of PZ and ZPI and their association with stroke. |
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| Keywords: | protein Z protein Z-dependent protease inhibitor stroke |
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