血清前S_1蛋白在HBV检测中临床意义

目的探讨血清前S1蛋白检测在乙型肝炎(乙肝)中含量的变化及意义。方法采用ELISA法对40例非乙肝患者和138例乙肝患者进行了血清前S1蛋白的检测。结果40例非乙肝患者血清前S1蛋白全部阴性。138例乙肝患者中前S1蛋白的阳性率为31.2%,其中急性肝炎为91.1%,慢性活动性肝炎为52.1%;在乙肝两对半检测模式中,大三阳组该指标阳性率为89.3%,小三阳组为28.1%。以HBV-DNA检测为标准,前S1蛋白的灵敏度为95.2%,假阳性率为5.5%,总符合率为93.4%。结论检测血清前S1蛋白水平的变化对乙肝的病情的发生与发展密切相关。

Clinical significance of detection of serum pre S_1 protein in patients with hepatitis B

Objective To explore the changes of serum pre-S_1 protein in patients with hepatitis B and their significance.Methods Forty patients without hepatitis B,one hundred thirty-eight patients with hepatitis B were tested with ELISA method for levels of serum pre-S_1 protein.Results In 40 patients without hepatitis B,serological test was negative for pre-S_1 protein and in 138 patients with hepatitis B,the overall positive rate of pre-S_1 protein was 31.2%(91.1% for acute hepatitis B and 52.1% for chronic active hepatitis).In the serological test battery for hepatitis B,the positive rate of pre-S_1 protein was 89.3% in patients with positive HBsAg,HBeAg,HBcAb markers and 28.3% in those with only positive HBsAg,HBeAb and HBcAb markers.Taking positive HBV-DNA as the diagnostic criterium,the sensitivity of pre-S_1 pretein was 95.2%,and overall conincidence was 93.4%.Conclusion Detection of pre-S_1 levels was associated the occurrence and development of hepatitis B.